Syndrome is a medical drama set in the neurosurgery world. Lee Hae-Jo is a first year resident specializing in neurosurgery. She didn't graduate from a premiere medical school, but she is determined to become the best neurosurgeon. Cha Yeo-Wook is also a first year neurosurgery resident. Unlike Hae-Jo, Cha Yeo-Wook graduated from the best medical school and is the grandson of the chairman of the board at the Korea University Hospital. His background to become a doctor is impecable. Kang Eun-Hyun is the chief resident of neurosurgery. A love triangle begins between these three people.